A yeast-based assay identifies drugs active against human mitochondrial disorders

Due to the lack of relevant animal models, development of effective treatments for human mitochondrial diseases has been limited. Here we establish a rapid, yeast-based assay to screen for drugs active against human inherited mitochondrial diseases affecting ATP synthase, in particular NARP (neuropa...

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Detalhes bibliográficos
Main Authors: Couplan, Elodie, Aiyar, Raeka S., Kucharczyk, Roza, Kabala, Anna, Ezkurdia, Nahia, Gagneur, Julien, St. Onge, Robert P., Salin, Bénédicte, Soubigou, Flavie, Le Cann, Marie, Steinmetz, Lars M., di Rago, Jean-Paul, Blondel, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141935/
https://ncbi.nlm.nih.gov/pubmed/21715656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101478108
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