Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders

Mitochondrial diseases are systemic, prevalent and often fatal; yet treatments remain scarce. Identifying molecular intervention points that can be therapeutically targeted remains a major challenge, which we confronted via a screening assay we developed. Using yeast models of mitochondrial ATP synt...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Aiyar, Raeka S., Bohnert, Maria, Duvezin-Caubet, Stéphane, Voisset, Cécile, Gagneur, Julien, Fritsch, Emilie S., Couplan, Elodie, von der Malsburg, Karina, Funaya, Charlotta, Soubigou, Flavie, Courtin, Florence, Suresh, Sundari, Kucharczyk, Roza, Evrard, Justine, Antony, Claude, St.Onge, Robert P., Blondel, Marc, di Rago, Jean-Paul, van der Laan, Martin, Steinmetz, Lars M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284804/
https://ncbi.nlm.nih.gov/pubmed/25519239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6585
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