Salt Bridges Overlapping the Gonadotropin-Releasing Hormone Receptor Agonist Binding Site Reveal a Coincidence Detector for G Protein-Coupled Receptor Activation

G protein-coupled receptors (GPCRs) play central roles in most physiological functions, and mutations in them cause heritable diseases. Whereas crystal structures provide details about the structure of GPCRs, there is little information that identifies structural features that permit receptors to pa...

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Main Authors: Janovick, Jo Ann, Pogozheva, Irina D., Mosberg, Henry I., Conn, P. Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2011
Ábhair:
Cellular and Molecular
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141895/
https://ncbi.nlm.nih.gov/pubmed/21527534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.180869
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