An Engineered Viral Protease Exhibiting Substrate Specificity for a Polyglutamine Stretch Prevents Polyglutamine-Induced Neuronal Cell Death

BACKGROUND: Polyglutamine (polyQ)-induced protein aggregation is the hallmark of a group of neurodegenerative diseases, including Huntington's disease. We hypothesized that a protease that could cleave polyQ stretches would intervene in the initial events leading to pathogenesis in these diseas...

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Main Authors: Sellamuthu, Saravanan, Shin, Bae Hyun, Han, Hye-Eun, Park, Sang Min, Oh, Hye Jin, Rho, Seong-Hwan, Lee, Yong Jae, Park, Woo Jin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140514/
https://ncbi.nlm.nih.gov/pubmed/21799895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022554
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