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Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity
The exquisite selectivity and catalytic activity of enzymes have been shaped by the effects of positive and negative selection pressure during the course of evolution. In contrast, enzyme variants engineered by using in vitro screening techniques to accept novel substrates typically display a higher...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1100772/ https://ncbi.nlm.nih.gov/pubmed/15867160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500063102 |
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