Pharmacological Activation of Sirt1 Ameliorates Polyglutamine-Induced Toxicity through the Regulation of Autophagy

Intracellular accumulation of polyglutamine (polyQ)-expanded Huntingtin (Htt) protein is a hallmark of Huntington’s disease (HD). This study evaluated whether activation of Sirt1 by the anti-cancer agent, β-lapachone (β-lap), induces autophagy in human neuroblastoma SH-SY5Y cells, thereby reducing i...

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Detalhes bibliográficos
Main Authors: Shin, Bae Hyun, Lim, Yunki, Oh, Hye Jin, Park, Sang Min, Lee, Sun-Kyung, Ahnn, Joohong, Kim, Do Han, Song, Woo Keun, Kwak, Tae Hwan, Park, Woo Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677867/
https://ncbi.nlm.nih.gov/pubmed/23762270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064953
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