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Autophagy and polyglutamine diseases
In polyglutamine diseases, an abnormally elongated polyglutamine tract results in protein misfolding and accumulation of intracellular aggregates. The length of the polyglutamine expansion correlates with the tendency of the mutant protein to aggregate, as well as with neuronal toxicity and earlier...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Pergamon Press
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712188/ https://ncbi.nlm.nih.gov/pubmed/21930185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2011.08.013 |
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