Polyglutamine tracts regulate beclin 1-dependent autophagy

Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, like huntingtin in Huntington’s disease (HD) and ataxin-3 in spinocerebellar ataxia type 3 (SCA3)1, 2. Age-at-onset decreases with increasing polyglutamine length in these proteins and the norm...

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Bibliografske podrobnosti
izdano v:Nature
Main Authors: Ashkenazi, Avraham, Bento, Carla F., Ricketts, Thomas, Vicinanza, Mariella, Siddiqi, Farah, Pavel, Mariana, Squitieri, Ferdinando, Hardenberg, Maarten C., Imarisio, Sara, Menzies, Fiona M., Rubinsztein, David C.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420314/
https://ncbi.nlm.nih.gov/pubmed/28445460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22078
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