Repair of chromosomal abasic sites in vivo involves at least three different repair pathways

We introduced multiple abasic sites (AP sites) in the chromosome of repair-deficient mutants of Escherichia coli, in vivo, by expressing engineered variants of uracil-DNA glycosylase that remove either thymine or cytosine. After introduction of AP sites, deficiencies in base excision repair (BER) or...

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Bibliographic Details
Published in:EMBO J
Main Authors: Otterlei, Marit, Kavli, Bodil, Standal, Rune, Skjelbred, Camilla, Bharati, Sangeeta, Krokan, Hans Einar
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2000
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314018/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11032821/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.20.5542
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