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Immunoglobulin secretion by B1 cells: Differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells

Peritoneal B1 cells are typified by spontaneous, constitutive secretion of IgM natural antibody, detected by ELISPOT assay, among other means. Recently, this key characteristic has been called into question, a reason for which we evaluated the integrity of IgM(+) ELISPOT spots. We found that fixed B...

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Detalhes bibliográficos
Principais autores: Holodick, Nichol E., Tumang, Joseph R., Rothstein, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139744/
https://ncbi.nlm.nih.gov/pubmed/21061433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040545
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