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BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

Bone morphogenetic protein-2 (BMP-2) induces bone formation and regeneration in adult vertebrates and regulates important developmental processes in all animals. BMP-2 is a homodimeric cysteine knot protein that, as a member of the transforming growth factor-β (TGF-β) superfamily, signals by oligome...

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Hlavní autoři: Kirsch, Thomas, Nickel, Joachim, Sebald, Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC313944/
https://ncbi.nlm.nih.gov/pubmed/10880444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.13.3314
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