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Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding

Bone morphogenetic proteins (BMPs) orchestrate key cellular events, such as proliferation and differentiation, in development and homeostasis. Extracellular antagonists, such as chordin, are essential regulators of BMP signaling. Chordin binds to BMPs blocking interaction with receptors, and cleavag...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Troilo, Helen, Zuk, Alexandra V., Tunnicliffe, Richard B., Wohl, Alexander P., Berry, Richard, Collins, Richard F., Jowitt, Thomas A., Sengle, Gerhard, Baldock, Clair
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246984/
https://ncbi.nlm.nih.gov/pubmed/25157165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404166111
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