Poly(ADP-ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells

5-Fluorouracil (5-FU) and 5-fluorodeoxyuridine (FdUrd, floxuridine) have activity in multiple tumors, and both agents undergo intracellular processing to active metabolites that disrupt RNA and DNA metabolism. These agents cause imbalances in dNTP levels and the accumulation of uracil and 5-FU in th...

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Bibliografiset tiedot
Päätekijät: Huehls, Amelia M., Wagner, Jill M., Huntoon, Catherine J., Geng, Liyi, Erlichman, Charles, Patel, Anand G., Kaufmann, Scott H., Karnitz, Larry M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138894/
https://ncbi.nlm.nih.gov/pubmed/21613406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0814
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