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Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination

5-Fluorouracil (5-FU) and its metabolite 5-fluorodeoxyuridine (FdUrd, floxuridine) are chemotherapy agents that are converted to 5-fluorodeoxyuridine monophosphate (FdUMP) and 5-fluorodeoxyuridine triphosphate (FdUTP). FdUMP inhibits thymidylate synthase and causes the accumulation of uracil in the...

詳細記述

保存先:
書誌詳細
出版年:Mol Pharmacol
主要な著者: Huehls, Amelia M., Huntoon, Catherine J., Joshi, Poorval M., Baehr, Carly A., Wagner, Jill M., Wang, Xiaoxiao, Lee, Marietta Y., Karnitz, Larry M.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702102/
https://ncbi.nlm.nih.gov/pubmed/26494862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.100164
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