Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous Recombination

5-Fluorouracil (5-FU) and its metabolite 5-fluorodeoxyuridine (FdUrd, floxuridine) are chemotherapy agents that are converted to 5-fluorodeoxyuridine monophosphate (FdUMP) and 5-fluorodeoxyuridine triphosphate (FdUTP). FdUMP inhibits thymidylate synthase and causes the accumulation of uracil in the...

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Foilsithe in:Mol Pharmacol
Main Authors: Huehls, Amelia M., Huntoon, Catherine J., Joshi, Poorval M., Baehr, Carly A., Wagner, Jill M., Wang, Xiaoxiao, Lee, Marietta Y., Karnitz, Larry M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2016
Ábhair:
Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702102/
https://ncbi.nlm.nih.gov/pubmed/26494862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.100164
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