Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil

The fluoropyrimidines 5-fluorouracil (5-FU) and FdUrd (5-fluorodeoxyuridine; floxuridine) are the backbone of chemotherapy regimens for colon cancer and other tumors. Despite their widespread use, it remains unclear how these agents kill tumor cells. Here, we have analyzed the checkpoint and DNA rep...

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Hauptverfasser: Geng, Liyi, Huehls, Amelia M., Wagner, Jill M., Huntoon, Catherine J., Karnitz, Larry M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240632/
https://ncbi.nlm.nih.gov/pubmed/22194930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028862
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