Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil

The fluoropyrimidines 5-fluorouracil (5-FU) and FdUrd (5-fluorodeoxyuridine; floxuridine) are the backbone of chemotherapy regimens for colon cancer and other tumors. Despite their widespread use, it remains unclear how these agents kill tumor cells. Here, we have analyzed the checkpoint and DNA rep...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Geng, Liyi, Huehls, Amelia M., Wagner, Jill M., Huntoon, Catherine J., Karnitz, Larry M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2011
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240632/
https://ncbi.nlm.nih.gov/pubmed/22194930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028862
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia