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Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil

The fluoropyrimidines 5-fluorouracil (5-FU) and FdUrd (5-fluorodeoxyuridine; floxuridine) are the backbone of chemotherapy regimens for colon cancer and other tumors. Despite their widespread use, it remains unclear how these agents kill tumor cells. Here, we have analyzed the checkpoint and DNA rep...

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Detalhes bibliográficos
Main Authors: Geng, Liyi, Huehls, Amelia M., Wagner, Jill M., Huntoon, Catherine J., Karnitz, Larry M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3240632/
https://ncbi.nlm.nih.gov/pubmed/22194930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028862
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