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Preparation of a Series of 5-Methyl-3-(substituted)-[1,2,4]triazines
Procedures for the synthesis of thirty-six 5-methyl-3-(substituted)-[1,2,4]triazines have been described. These compounds were evaluated for antagonism at metabotropic glutamate receptor subtype 5. Two compounds, 5b and 3c, were determined to be low micromolar inhibitors of mGluR5.
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138555/ https://ncbi.nlm.nih.gov/pubmed/21779134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2011.04.075 |
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