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Molecular Dynamics Analysis of Conserved Hydrophobic and Hydrophilic Bond Interaction Networks in ErbB Family Kinases

The EGFR/ErbB/HER family of kinases contains four homologous receptor tyrosine kinases that are important regulatory elements in key signaling pathways. To elucidate the atomistic mechanisms of dimerization-dependent activation in the ErbB family, we have performed molecular dynamics simulations of...

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Bibliografiske detaljer
Main Authors: Shih, Andrew J., Telesco, Shannon E., Choi, Sung Hee, Lemmon, Mark A., Radhakrishnan, Ravi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138537/
https://ncbi.nlm.nih.gov/pubmed/21426301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101791
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