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Molecular Modeling of the ErbB4/HER4 Kinase in the Context of the HER4 Signaling Network Helps Rationalize the Effects of Clinically Identified HER4 Somatic Mutations on the Cell Phenotype
In the ErbB/HER family of receptor tyrosine kinases, the deregulation of the EGFR/ErbB1/HER1, HER2/ErbB2, and HER3/ErbB3 kinases is associated with several cancers, while the HER4/ErbB4 kinase has been shown to play an anti-carcinogenic role in certain tumors. We present molecular and network models...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3934553/ https://ncbi.nlm.nih.gov/pubmed/24318637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201300022 |
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