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A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network

Multiscale modeling provides a powerful and quantitative platform for investigating the complexity inherent in intracellular signaling pathways and rationalizing the effects of molecular perturbations on downstream signaling events and ultimately, on the cell phenotype. Here we describe the applicat...

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Detalhes bibliográficos
Main Authors: Telesco, Shannon E., Shih, Andrew J., Jia, Fei, Radhakrishnan, Ravi
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138520/
https://ncbi.nlm.nih.gov/pubmed/21509365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0mb00345j
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