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Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases

The ErbB/EGFR/HER family of kinases consists of four homologous receptor tyrosine kinases which are important regulatory elements in many cellular processes, including cell proliferation, differentiation, and migration. Somatic mutations in, or over-expression of, the ErbB family is found in many ca...

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Bibliographic Details
Main Authors: Shih, Andrew J., Telesco, Shannon E., Radhakrishnan, Ravi
Format: Artigo
Language:Inglês
Published: Molecular Diversity Preservation International (MDPI) 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119571/
https://ncbi.nlm.nih.gov/pubmed/21701703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers3011195
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