A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation

Endoplasmic reticulum-associated degradation (ERAD) employs membrane-bound ubiquitin ligases and the translocation-driving ATPase p97 to retrotranslocate misfolded proteins for proteasomal degradation. How retrotranslocated polypeptides bearing exposed hydrophobic motifs or transmembrane domains (TM...

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Autors principals: Wang, Qiuyan, Liu, Yanfen, Soetandyo, Nia, Baek, Kheewoong, Hegde, Ramanujan, Ye, Yihong
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138499/
https://ncbi.nlm.nih.gov/pubmed/21636303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.05.010
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