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USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation
Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD). A surprising paradox emerging from recent studies is that ubiquitin ligases (E...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
eLife Sciences Publications, Ltd
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889402/ https://ncbi.nlm.nih.gov/pubmed/24424410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01369 |
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