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gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum

Eukaryotic cells eliminate misfolded proteins from the endoplasmic reticulum (ER) via a conserved process termed ER-associated degradation (ERAD). Central regulators of the ERAD system are membrane-bound ubiquitin ligases, which are thought to channel misfolded proteins through the ER membrane durin...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Biol Cell
Prif Awduron: Zhang, Ting, Xu, Yue, Liu, Yanfen, Ye, Yihong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666138/
https://ncbi.nlm.nih.gov/pubmed/26424800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-06-0354
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