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A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation
Endoplasmic reticulum-associated degradation (ERAD) employs membrane-bound ubiquitin ligases and the translocation-driving ATPase p97 to retrotranslocate misfolded proteins for proteasomal degradation. How retrotranslocated polypeptides bearing exposed hydrophobic motifs or transmembrane domains (TM...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138499/ https://ncbi.nlm.nih.gov/pubmed/21636303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.05.010 |
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