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Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells
In eukaryotes, deubiquitinases (DUBs) remove ubiquitin conjugates from diverse substrates, altering their stabilities, localizations or activities. Here we show that many DUBs of the USP and UCH subfamilies can be reversibly inactivated upon oxidation by reactive oxygen species in vitro and in cells...
में बचाया:
| मुख्य लेखकों: | , , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Nature Pub. Group
2013
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3615374/ https://ncbi.nlm.nih.gov/pubmed/23463011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2532 |
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