Astrocytes as determinants of disease progression in inherited ALS

Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease characterized by loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial...

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Hlavní autoři: Yamanaka, Koji, Chun, Seung Joo, Boillee, Severine, Fujimori-Tonou, Noriko, Yamashita, Hirofumi, Gutmann, David H., Takahashi, Ryosuke, Misawa, Hidemi, Cleveland, Don W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137510/
https://ncbi.nlm.nih.gov/pubmed/18246065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn2047
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