Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

There is compelling evidence that glial-immune interactions contribute to the progression of neurodegenerative diseases. The adaptive immune response has been implicated in disease processes of amyotrophic lateral sclerosis (ALS), but it remains unknown if innate immune signaling also contributes to...

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izdano v:Cell Death Differ
Main Authors: Komine, Okiru, Yamashita, Hirofumi, Fujimori-Tonou, Noriko, Koike, Masato, Jin, Shijie, Moriwaki, Yasuhiro, Endo, Fumito, Watanabe, Seiji, Uematsu, Satoshi, Akira, Shizuo, Uchiyama, Yasuo, Takahashi, Ryosuke, Misawa, Hidemi, Yamanaka, Koji
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261996/
https://ncbi.nlm.nih.gov/pubmed/29568058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0098-3
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