Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We,...

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Autors principals: Hoffmann, Ulrike, Lee, Jeong Hyun, Qin, Tao, Eikermann-Haerter, Katharina, Ayata, Cenk
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137475/
https://ncbi.nlm.nih.gov/pubmed/21505480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.50
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