Gabapentin suppresses cortical spreading depression susceptibility

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its α(2)δ subunit, on CSD...

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Autori principali: Hoffmann, Ulrike, Dileköz, Ergin, Kudo, Chiho, Ayata, Cenk
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2010
Soggetti:
Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949257/
https://ncbi.nlm.nih.gov/pubmed/20588320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.92
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