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Gabapentin suppresses cortical spreading depression susceptibility
Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its α(2)δ subunit, on CSD...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949257/ https://ncbi.nlm.nih.gov/pubmed/20588320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.92 |
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