Gabapentin suppresses cortical spreading depression susceptibility

Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its α(2)δ subunit, on CSD...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hoffmann, Ulrike, Dileköz, Ergin, Kudo, Chiho, Ayata, Cenk
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
Schlagworte:
Brief Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949257/
https://ncbi.nlm.nih.gov/pubmed/20588320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.92
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