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Gabapentin suppresses cortical spreading depression susceptibility
Cortical spreading depression (CSD) is an intense depolarization wave implicated in the pathophysiology of brain injury states and migraine aura. As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its α(2)δ subunit, on CSD...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2949257/ https://ncbi.nlm.nih.gov/pubmed/20588320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.92 |
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