Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations

Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hoffmann, Ulrike, Lee, Jeong Hyun, Qin, Tao, Eikermann-Haerter, Katharina, Ayata, Cenk
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2011
Pynciau:
Brief Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137475/
https://ncbi.nlm.nih.gov/pubmed/21505480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.50
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