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Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations
Spreading depression (SD) is an intense depolarization wave implicated in brain injury. In focal ischemia, recurrent peri-infarct depolarization (PID) waves akin to SD worsen the ischemic injury by exacerbating the blood flow-metabolism mismatch. We recently showed that gabapentin suppresses SD. We,...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137475/ https://ncbi.nlm.nih.gov/pubmed/21505480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.50 |
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