Inhibition of the P2X7–PANX1 complex suppresses spreading depolarization and neuroinflammation

Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and forms a pore complex with the ligand-gated cation channel P2X7, allowing the release of excitatory neurotransmitters to sustai...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Chen, Shih-Pin, Qin, Tao, Seidel, Jessica L., Zheng, Yi, Eikermann, Matthias, Ferrari, Michel D., van den Maagdenberg, Arn M. J. M., Moskowitz, Michael A., Ayata, Cenk, Eikermann-Haerter, Katharina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526725/
https://ncbi.nlm.nih.gov/pubmed/28430869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awx085
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