Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origin of spreading injury depolarizations

Peri-infarct depolarizations (PIDs) are seemingly spontaneous spreading depression-like waves that negatively impact tissue outcome in both experimental and human stroke. Factors triggering PIDs are unknown. Here, we show that somatosensory activation of peri-infarct cortex triggers PIDs when the ac...

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Bibliographic Details
Published in:Neuron
Main Authors: von Bornstädt, Daniel, Houben, Thijs, Seidel, Jessica, Zheng, Yi, Dilekoz, Ergin, Qin, Tao, Sandow, Nora, Kura, Sreekanth, Eikermann-Haerter, Katharina, Endres, Matthias, Boas, David A., Moskowitz, Michael A., Lo, Eng H., Dreier, Jens P., Woitzik, Johannes, Sakadžić, Sava, Ayata, Cenk
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351476/
https://ncbi.nlm.nih.gov/pubmed/25741731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.02.007
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