D-Glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo

BACKGROUND: D-Glucuronyl C5-epimerase (GLCE) is a key enzyme involved in the biosynthesis of heparan sulphate proteoglycans, which has an important role in cell–cell and cell–matrix interactions and signalling. Decreased GLCE expression in human breast tumours and its anti-proliferative effects in b...

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Bibliografiska uppgifter
Huvudupphovsmän: Grigorieva, E V, Prudnikova, T Y, Domanitskaya, N V, Mostovich, L A, Pavlova, T V, Kashuba, V I, Zabarovsky, E R
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2011
Ämnen:
Translational Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137399/
https://ncbi.nlm.nih.gov/pubmed/21654676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.170
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