D-Glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo

BACKGROUND: D-Glucuronyl C5-epimerase (GLCE) is a key enzyme involved in the biosynthesis of heparan sulphate proteoglycans, which has an important role in cell–cell and cell–matrix interactions and signalling. Decreased GLCE expression in human breast tumours and its anti-proliferative effects in b...

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Hlavní autoři: Grigorieva, E V, Prudnikova, T Y, Domanitskaya, N V, Mostovich, L A, Pavlova, T V, Kashuba, V I, Zabarovsky, E R
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137399/
https://ncbi.nlm.nih.gov/pubmed/21654676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.170
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