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Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: analysis by flow cytometry

Cell synchronization is often achieved by inhibition of DNA replication. The cells cultured in the presence of such inhibitors as hydroxyurea, aphidicolin or thymidine become arrested at the entrance to S-phase and upon release from the block they synchronously progress through S, G(2) and M. We rec...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Darzynkiewicz, Zbigniew, Halicka, H. Dorota, Zhao, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137244/
https://ncbi.nlm.nih.gov/pubmed/21755443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-61779-182-6_6
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