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Cytometric Assessment of DNA Damage Induced by DNA Topoisomerase Inhibitors
Exposure of cells to inhibitors of DNA topoisomerase I (topo I) or topoisomerase II (topo II) leads to DNA damage that often involves formation of DNA double-strand breaks (DSBs). DNA damage, particularly induction of DSBs, manifests by phosphorylation of histone H2AX on Ser-139 which is mediated by...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3873872/ https://ncbi.nlm.nih.gov/pubmed/19763948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60761-340-4_12 |
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