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Cytometric Assessment of DNA Damage Induced by DNA Topoisomerase Inhibitors

Exposure of cells to inhibitors of DNA topoisomerase I (topo I) or topoisomerase II (topo II) leads to DNA damage that often involves formation of DNA double-strand breaks (DSBs). DNA damage, particularly induction of DSBs, manifests by phosphorylation of histone H2AX on Ser-139 which is mediated by...

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Autori principali: Darzynkiewicz, Zbigniew, Halicka, Dorota H., Tanaka, Toshiki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3873872/
https://ncbi.nlm.nih.gov/pubmed/19763948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-60761-340-4_12
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