Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling

Mice with thyroid-specific expression of oncogenic BRAF (Tg-Braf) develop papillary thyroid cancers (PTC) that are locally invasive and have well-defined foci of poorly differentiated carcinoma (PDTC). To investigate the PTC-PDTC progression, we performed a microarray analysis using RNA from paired...

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Main Authors: Knauf, Jeffrey A, Sartor, Maureen A, Medvedovic, Mario, Lundsmith, Emma, Ryder, Mabel, Salzano, Marcella, Nikiforov, Yuri E, Giordano, Thomas J, Ghossein, Ronald A, Fagin, James A
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136543/
https://ncbi.nlm.nih.gov/pubmed/21383698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.44
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