Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E(2) pathway

Inflammatory pain represents an important unmet clinical need with important socioeconomic implications. Ceramide, a potent proinflammatory sphingolipid, has been shown to elicit mechanical hyperalgesia, but the mechanisms remain largely unknown. We now demonstrate that, in addition to mechanical hy...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Doyle, Tim, Chen, Zhoumou, Muscoli, Carolina, Obeid, Lina M., Salvemini, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2011
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136338/
https://ncbi.nlm.nih.gov/pubmed/21551240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-178095
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi