Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E(2) pathway

Inflammatory pain represents an important unmet clinical need with important socioeconomic implications. Ceramide, a potent proinflammatory sphingolipid, has been shown to elicit mechanical hyperalgesia, but the mechanisms remain largely unknown. We now demonstrate that, in addition to mechanical hy...

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Hauptverfasser: Doyle, Tim, Chen, Zhoumou, Muscoli, Carolina, Obeid, Lina M., Salvemini, Daniela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2011
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136338/
https://ncbi.nlm.nih.gov/pubmed/21551240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-178095
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