Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

Cellular immune control of HIV is mediated, in part, by induction of single amino acid mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we sought to determine if higher order constraints on viral evolution exist, because some coordinately linked combinations o...

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書誌詳細
主要な著者: Dahirel, Vincent, Shekhar, Karthik, Pereyra, Florencia, Miura, Toshiyuki, Artyomov, Mikita, Talsania, Shiv, Allen, Todd M., Altfeld, Marcus, Carrington, Mary, Irvine, Darrell J., Walker, Bruce D., Chakraborty, Arup K.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2011
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136285/
https://ncbi.nlm.nih.gov/pubmed/21690407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105315108
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