Predicting the Immunogenicity of T cell epitopes: From HIV to SARS-CoV-2

We describe a physics-based learning model for predicting the immunogenicity of Cytotoxic T Lymphocyte (CTL) epitopes derived from diverse pathogens, given a Human Leukocyte Antigen (HLA) genotype. The model was trained and tested on experimental data on the relative immunodominance of CTL epitopes...

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Bibliographic Details
Published in:bioRxiv
Main Authors: Gao, Ang, Chen, Zhilin, Segal, Florencia Pereyra, Carrington, Mary, Streeck, Hendrik, Chakraborty, Arup K., Julg, Boris
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7241102/
https://ncbi.nlm.nih.gov/pubmed/32511339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.14.095885
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