Statistical Linkage Analysis of Substitutions in Patient-Derived Sequences of Genotype 1a Hepatitis C Virus Nonstructural Protein 3 Exposes Targets for Immunogen Design

Chronic hepatitis C virus (HCV) infection is one of the leading causes of liver failure and liver cancer, affecting around 3% of the world's population. The extreme sequence variability of the virus resulting from error-prone replication has thwarted the discovery of a universal prophylactic va...

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Autori principali: Quadeer, Ahmed A., Louie, Raymond H. Y., Shekhar, Karthik, Chakraborty, Arup K., Hsing, I-Ming, McKay, Matthew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Cellular Response to Infection
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054436/
https://ncbi.nlm.nih.gov/pubmed/24760894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03812-13
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