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ValC, a New Type of C7-Cyclitol Kinase Involved in the Biosynthesis of the Antifungal Agent Validamycin A

The gene valC encoding an enzyme homologous to the 2-epi-5-epi-valiolone kinase (AcbM) of the acarbose biosynthetic pathway was identified in the validamycin A biosynthetic gene cluster. Inactivation of valC resulted in mutants that lack the ability to produce validamycin A. Complementation experime...

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Detalhes bibliográficos
Main Authors: Minagawa, Kazuyuki, Zhang, Yirong, Ito, Takuya, Bai, Linquan, Deng, Zixin, Mahmud, Taifo
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136165/
https://ncbi.nlm.nih.gov/pubmed/17335096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200600528
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