Functional Analysis of the Validamycin Biosynthetic Gene Cluster and Engineered Production of Validoxylamine A

A 45 kb DNA sequencing analysis from Streptomyces hygroscopicus 5008 involved in validamycin A (VAL-A) biosynthesis revealed 16 structural, 2 regulatory, and 5 genes related to transport, transposition/integration, tellurium resistance, and another 4 genes with no obvious identity. The VAL-A biosynt...

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Autori principali: Bai, Linquan, Li, Lei, Xu, Hui, Minagawa, Kazuyuki, Yu, Yi, Zhang, Yirong, Zhou, Xiufen, Floss, Heinz G., Mahmud, Taifo, Deng, Zixin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474575/
https://ncbi.nlm.nih.gov/pubmed/16632251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2006.02.002
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