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Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations
BACKGROUND: Factor VIII consists of a heavy chain (A1A2B domains) and light chain (A3C1C2 domains), while the contiguous A1A2 domains are separate subunits in the cofactor, factor VIIIa. Recently we reported that procofactor stability at elevated temperature and cofactor stability over an extended t...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3136035/ https://ncbi.nlm.nih.gov/pubmed/19067791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2008.03256.x |
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