A New Generation of Serotype Chimeric Infectivity-Enhanced Conditionally Replicative Adenovirals: The Safety Profile of Ad5/3-Δ24 in Advance of a Phase I Clinical Trial in Ovarian Cancer Patients

Conditionally replicative adenoviral (CRAd) virotherapy represents a promising therapeutic approach for cancer. We have demonstrated that a serotype chimeric adenoviral 5/3 fiber-knob modification achieves enhanced ovarian cancer infectivity, conditional replication, and oncolytic activity. This stu...

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Bibliografiske detaljer
Main Authors: Kim, Kenneth H., Ryan, Michael J., Estep, James E., Miniard, Brock M., Rudge, Thomas L., Peggins, James O., Broadt, Trevor L., Wang, Minghui, Preuss, Meredith A., Siegal, Gene P., Hemminki, Akseli, Harris, Raymond D., Aurigemma, Rosemarie, Curiel, David T., Alvarez, Ronald D.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135257/
https://ncbi.nlm.nih.gov/pubmed/21171861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.180
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