A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer

PURPOSE: Ad5.SSTR/TK.RGD is an infectivity-enhanced adenovirus expressing a therapeutic thymidine kinase suicide gene and a somatostatin receptor that allows for noninvasive gene transfer imaging. The purpose of this study was to identify the MTD, toxicities, clinical efficacy and biologic effects o...

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Hauptverfasser: Kim, Kenneth H., Dmitriev, Igor, O’Malley, Janis P., Wang, Minghui, Saddekni, Souheil, You, Zhiying, Preuss, Meredith A., Harris, Raymond D., Aurigemma, Rosemarie, Siegal, Gene P., Zinn, Kurt R., Curiel, David T., Alvarez, Ronald D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065594/
https://ncbi.nlm.nih.gov/pubmed/22510347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2852
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