A Phase I Clinical Trial of Ad5/3-Δ24, a Novel Serotype-Chimeric, Infectivity-Enhanced, Conditionally-Replicative Adenovirus (CRAd), in Patients with Recurrent Ovarian Cancer

OBJECTIVE: The conditionally replicative adenovirus Ad5/3-Δ24 has a type-3 knob incorporated into the type-5 fiber that facilitates enhanced ovarian cancer infectivity. Preclinical studies have shown that Ad5/3-Δ24 achieves significant oncolysis and antitumor activity in ovarian cancer models. The p...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Kenneth H., Dmitriev, Igor P., Saddekni, Souheil, Kashentseva, Elena A., Harris, Raymond D., Aurigemma, Rosemarie, Bae, Sejong, Singh, Karan P., Siegal, Gene P., Curiel, David T., Alvarez, Ronald D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748258/
https://ncbi.nlm.nih.gov/pubmed/23756180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2013.06.003
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